Follow us on:



How to combine two of hottest cosmetic trends in just one ingredient?...Sederma did it!
Sederma has chosen to produce its new product Resistem™ by plant cell culture as this technology is an inexhaustible source of metabolites of interest that provides numerous benefits pertaining to sustainability, safety, quality and sourcing. Positioned as a high tech anti-ageing ingredient, it mimics the natural hormetic phenomenon of defence.

With skin being exposed daily to various stresses such as UVAB, stress, pollution, smoke, junk food, noxious agents are generated; these noxious agents lead to an accumulation of toxins in the keratinocytes which not only contributes to premature skin ageing and skin sensitivity, but which also increases redness and reduces the skin’s natural glow.

Resistem™ is able to reproduce a hormetic response in the skin cells that develops a genuine defence system in the heart of the skin. A complex and diverse in vitro evaluation has proven Resistem™’s positive effect on:

  • tissue regeneration by preservation of skin stem cells character and niche,
  • cell detoxification by maintenance of proteasome activity,
  • cell longevity by stimulation of the sirtuin-1 synthesis.

Resistem™ is an anti-ageing “bodyguard” of the skin. It helps skin to naturally decrease the level of pro-ageing agents while reducing the toxin-induced micro inflammations. In vivo studies demonstrated its ability to soothe the skin, reduce redness, improve the evenness of the complexion and restore its natural glow. The skin feels appeased and reveals a much fresher look. Through a virtuous circle, Resistem™ recreates its own beauty!

Beautifully immunized against time.

Resistem anti ageing active ingredient
Arrow View product details
Login to the Sederma Direct
Customer Extranet in order to:
Arrow Download promotional sheet
Arrow Download formulations
Arrow Order sample

Discover Sederma's anti-ageing products