Matrixyl® 3000 - New study reconfirms previous findings
Matrixyl® has been recognised with the 25 Years of Innovation Award during in-cosmetics 2015 -
Remember, mid 2011, Sederma was presenting a new in vivo test demonstrating the protective effect against photo-induced ageing of Matrixyl® 3000, the well-known matrikine based anti-ageing/skin rejuvenating ingredient.
Today, a complementary approach is confirming Matrixyl® 3000’s repairing effect of the cutaneous damages of ageing. Now it is the Matrixyl® 3000’s ability to reverse chronological ageing that has been demonstrated with both in vitro and ex vivo studies.
First, Matrixyl® 3000 has been shown to regulate the expression of well-known (SA β-galactosidase) and recently discovered (progerin) markers of senescence. Indeed, it does not only reduce the SA β-galactosidase activity, but it also reduces the progerin's expression while preserving the expression of the normal form lamin A*.
Then, immunohistochemistry analysis of skin sections ex vivo has proved that Matrixyl® 3000 significantly stimulates synthesis of Collagen-I, -IV, -VII, -XVII and Nidogen-I proteins. While these proteins of the dermis and dermal-epidermal junction usually decrease with age, Matrixyl® 3000 rejuvenates the dermal structure.
These innovative tests and claims give you one more reason to claim “Matrixyl® inside” on your products.
Matrixyl® 3000 restores skin’s metabolism of youth.
*Lamins are key proteins in the skin’s regenerative process. Progerin is an altered form whose expression rises at the same time as skin ageing signs appear and intensify.