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Matrixyl® 3000 - New study reconfirms previous findings


Matrixyl® has been recognised with the 25 Years of Innovation Award during in-cosmetics 2015 - Read more


Remember, mid 2011, Sederma was presenting a new in vivo test demonstrating the protective effect against photo-induced ageing of Matrixyl® 3000, the well-known matrikine based anti-ageing/skin rejuvenating ingredient.

Today, a complementary approach is confirming Matrixyl® 3000’s repairing effect of the cutaneous damages of ageing. Now it is the Matrixyl® 3000’s ability to reverse chronological ageing that has been demonstrated with both in vitro and ex vivo studies.

First, Matrixyl® 3000 has been shown to regulate the expression of well-known (SA β-galactosidase) and recently discovered (progerin) markers of senescence. Indeed, it does not only reduce the SA β-galactosidase activity, but it also reduces the progerin's expression while preserving the expression of the normal form lamin A*.

Then, immunohistochemistry analysis of skin sections ex vivo has proved that Matrixyl® 3000 significantly stimulates synthesis of Collagen-I, -IV, -VII, -XVII and Nidogen-I proteins. While these proteins of the dermis and dermal-epidermal junction usually decrease with age, Matrixyl® 3000 rejuvenates the dermal structure.

These innovative tests and claims give you one more reason to claim “Matrixyl® inside” on your products.


Matrixyl® 3000 restores skin’s metabolism of youth.

*Lamins are key proteins in the skin’s regenerative process. Progerin is an altered form whose expression rises at the same time as skin ageing signs appear and intensify.

Matrixyl the well-known matrikine based anti-ageing ingredient

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Do you know the genuine story of Matrixyl®? Discover it on www.matrixylinside.com